Diaminopyrimidine P2X3 and P2X2 / 3 receptor modulators for treating acute, subacute or chronic cough

摘要

The present invention relates to diaminopyrimidine compounds having activity as antagonists of P2X purinergic receptors and methods for treating diseases associated with P2X receptors comprising administering an effective amount of a diaminopyrimidine compound. More particularly, methods of using P2X3 and / or P2X2 / 3 antagonists in the treatment of cough, chronic cough and impulse to cough in respiratory conditions and disorders are provided.