MRI contrast agents comprising T1 contrast material coated on the nanoparticle support surface

摘要

The present invention relates to a magnetic resonance imaging (MRI) T1 contrast agent composition comprising a T1 contrast material coated on the nanoparticle support surface. MRI T1 contrast agent compositions of the present invention, the nanoparticle support having a constant diameter, by modifying the T1 contrast agent material paramagnetic below a certain thickness, the surface area of the T1 contrast agent material - volume ratio increased (surface-to-volume ratio) is greatly, have excellent T1 magnetic spin relaxation effect. The present invention, by providing a more accurate and clearer T1 positive contrast (positive contrast) image, can be usefully employed to the reliability of high image diagnosis.FIELD 1