T1 MRI MRI CONTRAST AGENT INCLUDING T1 CONTRAST MATERIAL COATED ON SURFACE OF NANOPARTICLE SUPPORT

摘要

The present invention relates to a magnetic resonance imaging (MRI) T1 contrast agent composition comprising a contrast T1 material coated on the nanoparticles surface of the support. MRI T1 contrast agent compositions of the present invention certain nano by particle modifying the T1 contrast materials of paramagnetic below a predetermined thickness on the support T1 surface area of ​​the contrast agent material having a diameter - the superior T1 to increase significantly the volume ratio (surface-to-volume ratio) It has a magnetic spin relaxation effect. The invention can be usefully utilized for higher imaging reliability by providing a more precise and sharp contrast amount T1 (positive contrast) image.