HCV RNA-polymerase NS5B nucleoside inhibitor, 2-{(2R, 3S, 5R) -5- (4-amino-2-oxo-2H-pyrimidin-1-yl) -3-hydroxy-tetrahydro-furan -2-ylmethoxy -phenoxy-phosphorylamino} -alkyl propionate, process for its preparation and use

摘要

Compounds of general formula 1 or stereoisomers thereof, pharmaceutically acceptable salts and / or hydrates, solvates or crystalline forms thereof: wherein R1 is C1-C4 alkyl; R2 and R3 is fluoro, or R2 is fluoro, and R3 is methyl; R4 and R5 are H, or R4 is C1-C6 acyl, and R5 is hydrogen, or R4 Is hydrogen and R5 is C1-C6 acyl; R4 is an optionally substituted aminoacyl and R5 is hydrogen or R4 is hydrogen and R5 is optionally Optionally substituted aminoacyl; R6 is hydrogen, methyl, methoxy or halogen;