ALKYL 2-{(2R,3S,5R)-5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-3-HYDROXY-TETRAHYDRO-FURAN-2-YL-METHOXYPHENOXY-PHOSPHORYL-AMINO}PROPIONATES, NUCLEOSIDE INHIBITORS OF HCV NS5B RNA-POLYMERASE, METHODS FOR PRODUCTION AND USE THEREOF

摘要

Compounds of general formula 1 or stereoisomers thereof, their pharmaceutically acceptable salts and/or hydrates, solvates or crystalline forms:; ;wherein R¹ is C₁-C₄alkyl; R² and R³ are fluorine, or R² is fluorine, and R³ is methyl; R⁴ and R⁵ are hydrogen, or R⁴ is C₁-C₆ acyl, and R⁵ is hydrogen, or R⁴ is hydrogen, and R⁵ is C₁-C₆ acyl, or R⁴ is optionally substituted α-aminoacyl, and R⁵ is hydrogen, or R⁴ is hydrogen, and R⁵ is optionally substituted α-aminoacyl; R⁶ is hydrogen, methyl, methoxy or halogen.