How to identify periodontitis cause cell screening method of periodontitis treatment, the inspection method of periodontitis, test kits

摘要

Established are an analysis of markers of aggressive fibroblasts which are cells that cause periodontitis, screening of novel periodontitis therapeutics, a test method, and a test kit. As a result of analyzing aggressive fibroblasts, it has become apparent that expression from the P1 promoter of RUNX2 and expression of DLX5 are decreased to a greater extent than in normal gingival fibroblasts. An increase in expression of FLT1 was also seen. Using these expressions characteristic of aggressive fibroblasts as markers makes possible the identification of aggressive fibroblasts, a method for screening therapeutics, and a test method.