3,5-Diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficits associated with Down syndrome and Alzheimer's disease

摘要

The present invention relates to a compound of formula (I ′) or a pharmaceutically acceptable salt, solvate, or hydrate thereof, wherein X3 is F, OH, or SH, and Y3 is F, OH , Or SH, and X1, X2, X4, X5, Υ1, Y2, Y4, and Y5 are independently of each other H, F, Cl, Br, OH, or SH, and X1, X2, X4, And 1-2 of the X5 groups are not H and / or 1-2 of the Y1, Y2, Y4, and Y5 groups are not H. The invention also relates to compounds of formula (I ') for use as medicaments in the prevention and / or treatment of medicaments, particularly cognitive impairment associated with Dyrk1A protein dysfunction.