Influenza vaccination in early Alzheimer's disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

摘要

Alzheimer's disease(AD)is a neurodegenerative disorder strongly correlated with dysfunctional immune system.Our previous results demonstrated that inactivated influenza vaccine(IV)facilitated hippocampal neurogenesis.However,whether IV could improve cognitive deficits in AD mouse model remains unclear.