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Inhibitors of the enzyme DXS in the MEP pathway
Inhibitors of the enzyme DXS in the MEP pathway
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机译:MEP途径中的DXS酶抑制剂
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摘要
PROBLEM TO BE SOLVED: To provide a novel compound inhibiting an enzyme 1-deoxy D-xylulose 5-phosphate synthase (DXS) in a 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway which mainly prokaryons have, and to provide a DXS inhibitor containing the compound.;SOLUTION: There are provided: a compound represented by formula (1) wherein R is -OH or a 1-6C alkyl group, m is an integer of 0 to 3, and n is an integer of 3 to 20; and a DXS inhibitor containing the compound. The compound or the inhibitor exhibits growth inhibiting activity to related bactria (Mycobacterium smegmatis) of tubercle bacillus.;COPYRIGHT: (C)2014,JPO&INPIT
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