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Tissue regeneration promoter by mobilization of bone marrow mesenchymal and / or pluripotent stem cells in blood
Tissue regeneration promoter by mobilization of bone marrow mesenchymal and / or pluripotent stem cells in blood
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机译:通过动员血液中的骨髓间充质干细胞和/或多能干细胞来组织再生促进剂
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摘要
It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.
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