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Treatment of pancreatic developmental gene diseases by inhibition of natural antisense transcripts against pancreatic developmental genes

机译：通过抑制针对胰腺发育基因的天然反义转录本来治疗胰腺发育基因疾病

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摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Pancreatic Developmental gene, in particular, by targeting natural antisense polynucleotides of a Pancreatic Developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Pancreatic Developmental genes.

机译：本发明涉及特别是通过靶向胰腺发育基因的天然反义多核苷酸来调节胰腺发育基因的表达和/或功能的反义寡核苷酸。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与胰腺发育基因表达相关的疾病和病症中的用途。

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公开/公告号JP5963680B2

专利类型
公开/公告日2016-08-03

原文格式PDF
申请/专利权人カッパーアールエヌエー;インコーポレイテッド;
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申请/专利号JP20120548109
发明设计人コラド;ジョゼフ;コルコワシャーマン;オルガ;
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申请日2011-01-06
分类号C12N15/113;A61K31/7125;A61K31/712;A61K31/713;A61K48;A61P9/10;A61P9/04;A61P9/06;A61P29;A61P1/04;A61P1/14;A61P1/18;A61P35;A61P1/16;A61P19/08;A61P31/20;A61P19/10;A61P19/02;A61P17/06;A61P37/02;A61P21;A61P31;A61P25/04;A61P37/08;A61P11/02;A61P27/02;A61P21/04;A61P3/10;A61P37/06;A61P13/12;A61P13/10;A61P25/28;A61P25/16;A61P21/02;A61P3/04;A61P27/12;A61P3/06;A61P31/22;A61P25/24;
国家 JP
入库时间 2022-08-21 14:42:03

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