Recombinant particle-based vaccine against human cytomegalovirus infection

摘要

The present invention relates to prophylactic or therapeutic vaccines for human cytomegalovirus (HCMV) and other herpes viruses, and protein constructs in the form of genes and virus-like particles and protein complexes for use as diagnostic and research and development tools. . Virus-like particles include one or more capsid proteins from herpesviruses or retroviruses, three or more CMV surface proteins, and optionally the coat protein. The construct is prepared using a technique that combines recombinant DNA with disposable cell culture and purification techniques.