首页>
外国专利>
RESISTANT MUTANT 90 kDA HEAT SHOCK PROTEIN
RESISTANT MUTANT 90 kDA HEAT SHOCK PROTEIN
展开▼
机译:抗性突变体90 kDA热休克蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for treating the patients who have become resistant to known HSP90 inhibitors.;As a means for solving the above problems, the present invention provides identification of the patients based on a protein, which is an HSP90 family protein having a mutation in the site corresponding to F138 of HSP90α class A consisting of the amino acid sequence of SEQ ID NO: 1, and use of a substance that inhibits the protein as an active ingredient of a therapeutic agent.
展开▼
机译:本发明要解决的一个目的是鉴定对已知的HSP90抑制剂有抗药性的患者,并提供一种新颖的治疗剂来治疗对已知的HSP90抑制剂有抗药性的患者。本发明提供了基于蛋白质的患者鉴定,该蛋白质是在HSEQ90αA类的F138对应位点具有由SEQ ID NO:1的氨基酸序列组成的突变的HSP90家族蛋白,以及抑制蛋白质作为治疗剂的活性成分。
展开▼