首页>
外国专利>
Methods of Treating Hepatic Fibrosis and Associated Diseases by Regulating Rev-ERB Activity
Methods of Treating Hepatic Fibrosis and Associated Diseases by Regulating Rev-ERB Activity
展开▼
机译:调节Rev-ERB活性治疗肝纤维化及相关疾病的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is directed to compositions and associated methods for treatment, prevention, amelioration, and/or delaying the onset of hepatic fibrosis and/or associated diseases. The methods preferably involve regulating at least one of Rev-erbα expression, activity, and subcellular localization. In particular, certain embodiments of the present invention relate to compositions and methods of using a Rev-erb-modulating agent (REMA) for the treatment or prevention of hepatic fibrosis and/or associated diseases. Preferably, the amount of a REMA administered comprises a quantity sufficient to modulate at least one of Rev-erbα expression, activity, and subcellular localization and reduce the activation of hepatic stellate cells (HSCs).
展开▼