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Method For Predicting Responsiveness To Compound Inhibiting MAPK Signal Transduction Pathway
Method For Predicting Responsiveness To Compound Inhibiting MAPK Signal Transduction Pathway
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机译:预测复合抑制MAPK信号转导通路反应性的方法
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摘要
Provided are: a method of predicting sensitivity to a molecularly targeted drug; a method of selecting a patient who is determined to have high responsiveness to administration of a drug; and a reagent to be used in these methods. Specifically, provided are: a method of predicting responsiveness to cancer disease treatment with a compound that inhibits a mitogen-activated protein kinase (hereinafter abbreviated as MAPK) signaling pathway, the method including using a biological sample derived from a cancer patient, measuring whether or not β-catenin contained in the biological sample has at least one kind of mutation selected from the group consisting of (i) an active mutation and (ii) a substitution mutation of an asparagine residue to a serine residue at position 287; a method of selecting a patient to be subjected to cancer disease treatment with the compound; a method of treating a cancer disease, the method including administering the compound to the patient selected by the above-mentioned method; and a reagent to be used in these methods.
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