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DIRECT SYNTHESIS OF PH-RESPONSIVE POLYMER PARTICLES AND APPLICATION IN CONTROL RELEASE OF HYDROPHOBIC THERAPEUTIC COMPOUNDS
DIRECT SYNTHESIS OF PH-RESPONSIVE POLYMER PARTICLES AND APPLICATION IN CONTROL RELEASE OF HYDROPHOBIC THERAPEUTIC COMPOUNDS
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机译:PH响应性聚合物颗粒的直接合成及其在疏水性治疗化合物控制释放中的应用
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摘要
The present disclosure relates to a process for making a branched copolymer comprising reacting polymer monomers with macro-azo polyethylene glycol (PEG) initiators and cross-linkers, in the presence of a chain transfer agent, wherein said process comprises the step of traditional radical polymerization. The process further comprises a step of dialysis to obtain polymer nano-particles. The process further comprises the step of loading the polymer nanoparticles with a hydrophobic compound. The present disclosure also relates to the use of the polymer nanoparticles for the slow release of a hydrophobic compound in a neutral or alkaline environment or the fast release of a hydrophobic compound in an acidic environment.
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