Synthesis of core-shell coordination polymer nanoparticles (CPNs) for pH-responsive controlled drug release

摘要

Four types of physiologically unstable anticancer 'drug-metal' CPNs were 'shelled' with pH-responsive 'ligand-metal' CPs, which gives rise to a significant release of drug molecules under designated pH conditions and exhibited a higher cytotoxicity against HeLa cells than core CPNs and free drug.