METHOD OF OBTAINING EPIGENETIC INFORMATION OF CELL, METHOD OF DETERMINING CHARACTERISTICS OF CELL, METHOD OF DETERMINING DRUG SENSITIVITY OR SELECTING TYPE OF DRUG OR IMMUNOTHERAPEUTIC AGENT, METHOD OF DIAGNOSING DISEASE, SELF-REPLICATING VECTOR, ASSAY KIT AND ANALYTIC DEVICE

摘要

According to one embodiment, a method of obtaining epigenetic information of a subject cell containing a specific genome sequence is provided. The method includes, introducing a reporter nucleic acid construct into the cell, culturing the cell to promote the construct to self-replicate, detecting a signal produced, and obtaining the information. The construct contains a target sequence containing a base with a substitutable group, and having homology with the specific genome sequence. The construct transcribes a state of modification of the specific genome sequence onto the target sequence during the self-replication, by a substitution of the group in the target sequence. The construct produces a signal depending on a states of the substitution of the group in the target sequence.