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Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
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机译:使用共价键形成反应对的基于粒子的目标分子检测方法和组合物
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摘要
Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules having one or more members of a reactive pair are disclosed which can be used to increase the number of intra-complex binding interactions in a complex comprising a target molecule and a substrate. Intra-complex crosslinking and inter-complex crosslinking can be utilized in connection with these methods and compositions to further strengthen and stabilize the disclosed binding complexes.
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