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Lung cancer specific peptides for targeted drug delivery and molecular imaging
Lung cancer specific peptides for targeted drug delivery and molecular imaging
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机译:肺癌特异性多肽,用于靶向药物递送和分子成像
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摘要
A conjugate is disclosed. The conjugate comprises (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1-8; and (b) a component conjugated to the targeting peptide, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, a liposome, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. Methods of treating lung cancer and detecting lung cancer cells are also disclosed.
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机译:公开了缀合物。缀合物包含(a)长度少于15个氨基酸残基的分离的或合成的靶向肽,其包含与选自SEQ ID NO:1-8的序列具有至少90%同一性的氨基酸序列。 ; (b)与靶向肽缀合的组分,该组分选自药物输送载体,抗癌药,胶束,纳米颗粒,脂质体,聚合物,脂质,寡核苷酸,肽,多肽,蛋白质,细胞,显像剂和标记剂。还公开了治疗肺癌和检测肺癌细胞的方法。
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