TARGET SPECIFIC DRUG DELIVERY SYSTEM, TARGET NON-SPECIFIC LONG-ACTING DRUG DELIVERY SYSTEM AND METHOD OF CONTROLLING TARGET SPECIFICITY THEREOF

摘要

The present invention relates to a method of controlling the target specificity of drug delivery system including the hyaluronic acid (HA) derivative, a target specific drug delivery system and a target non-specific long-acting drug delivery system. The regulation of the substitution ratio of carboxyl group in HA derivative controls the target specific or target non-specific long-acting property of the drug delivery system including the HA derivative.