首页> 外国专利> APPLICATION OF ENROFLOXACIN SALT IN PREPARATION OF ORAL PREPARATION FOR PIGS

APPLICATION OF ENROFLOXACIN SALT IN PREPARATION OF ORAL PREPARATION FOR PIGS

机译:恩诺沙星盐在制备猪口服制剂中的应用

摘要

The invention discloses application of an enrofloxacin salt in preparation of an oral preparation for pigs. The enrofloxacin salt is at least one of salts formed by enrofloxacin and metal ions, and the metal ions are zinc, copper, calcium, magnesium, iron, cobalt, manganese, chromium, silver or nickel. The enrofloxacin salt formed by the enrofloxacin and the metal ions can significantly improve the palatability of the enrofloxacin to pigs; furthermore pharmacokinetics and artificial infection prove that the enrofloxacin salt formed by the enrofloxacin and the metal ions does not affect bioavailability, so enrofloxacin salt can be developed into the oral preparation administrated via the digestive tract, for pig-raising without affecting normal feed intake of the pigs.
机译:本发明公开了恩诺沙星盐在制备猪口服制剂中的应用。恩诺沙星盐是由恩诺沙星和金属离子形成的盐中的至少一种,并且金属离子是锌,铜,钙,镁,铁,钴,锰,铬,银或镍。由恩诺沙星和金属离子形成的恩诺沙星盐可以显着提高恩诺沙星对猪的适口性;进一步的药代动力学和人工感染证明,由恩诺沙星与金属离子形成的恩诺沙星盐不影响生物利用度,因此可以将恩诺沙星盐制成经消化道给药的口服制剂,用于养猪而不影响正常饲料的采食量。猪。

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