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Dynamic measurement of density using terahertz radiation with real-time thickness measurement for process control
Dynamic measurement of density using terahertz radiation with real-time thickness measurement for process control
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机译:使用太赫兹辐射动态测量密度并进行实时厚度测量以进行过程控制
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摘要
A method of determining a density of a roller compacted ribbon is disclosed. The method comprises compacting dry pharmaceutical powder between press rollers of a roller compactor to produce a compact ribbon. The method also comprises determining a thickness at a point on the compact ribbon in a non-invasive manner after it has rolled out from in between the press rollers. Further, the method comprises passing the compact ribbon through a gap in between the terahertz emitter and the terahertz detector. Next, the method comprises determining a refractive index at the point on the compact ribbon using a measurement value from the terahertz emitter and the terahertz detector and a measured value for the thickness at the point. Finally, the method comprises computing a density of the compact ribbon at the point using a value of the refractive index.
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