A Compound 1,4,5-Trisubstituted1,2,3-Triazole, Process To Obtain And Uses Thereof

摘要

The present invention relates to compounds, containing a central 1,4,5-trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent “click” bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compound are nonpeptide mimetics of RGD (Arg-Gly-Asp) and/or, OGP_10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides. Also, the present invention relates to a process for the preparation of the compounds containing a 1,4,5-trisubstituted 1,2,3-triazole core. These compounds are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices.