USE OF LYMPHOCYTE ACTIVATION GENE 3 (LAG-3) EXPRESSION PROFILING AS A BIOMARKER FOR ASSESSING INFLAMMASOMES, CHRONIC INFLAMMATORY DISEASES AND DYSFUNCTIONAL HDL

摘要

A method for determining whether a subject has or is predisposed to abnormal expression of inflammasomes and/or to dysfunctional HDL suitable for use in diagnosing atherosclerosis, chronic inflammatory disease, Incident Cardiovascular Disease (ICD) and other pathologies characterized by an inflammatory response. Specifically, a protein assay that measures LAG-3 can be used as a diagnostic predictor of pathologies such as infection, inflammation, chronic inflammatory disease, and coronary artery disease. The diagnostic is combined with the therapeutic use of a remediating drug for treatment.