Pharmaceutical aerosol Formulation for pressurised metered dose inhalers comprising a sequestering Agent, Inhaler and Method for filling

摘要

Claim 1: an aerosol preparation for a pressurized metered dose inhaler, characterized in that it is composed of 20 acetyl cholesterol, selected from budesonida, fluisolida, triamcinolona acetonida, dexametasona and betametasona, which is a liquefied hydrofluorocarbon compound. Cosmetics selected from alcohol suitable for drug use, as well as one selected from a group of kidnapping agents consisting of sulfuric acid and phosphoric acid, the chemical stability of the active ingredient is improving. Claim 2: an expression made in accordance with claim 1,It is characterized in that the liquefied hydrofluorocarbon is at least one element selected from the hydrofluorocarbon-134a, hydrofluorocarbon-227 and their mixtures. Claim 3: in accordance with claim 1 or claim 2, characterized by ethanol. 113. Claim 13: in accordance with the expression of claim 1, it is characterized by that 20 ethyl cholesterol is Buddhist. Claim 18: the method of filling the sprayer according to any one of 14 to 17 claims, which is characterized by: (a) adding 20 selected acetylcholesterol between budesonida, fluisolida and triamcinolon acetonida,1. Dexametasona and betametasona 17 valerato in one or more cosmetics; (b) fill the inhaler with this solution; (c) add a predetermined amount of kidnapping agent in phosphoric acid or sulfuric acid; (d) add a propellant containing hydrofluorocarbon in this solution;and (e) press-fit the valve and fill with gas; wherein said phosphoric acid is present in an amount equivalent to between 0.0004 and 0.040% w / w, preferably between 0.0008 and 0.020% w / w, more preferably between 0.001 and 0.010% w / w of 15 M phosphoric acid, calculated based on the total weight of the final solution, or where said sulfuric acid is present in an amount equivalent to between 0.0005 and 0.02% w / w, preferably between 0.001 and 0.01% w / w, more preferably between 0.001 and 0.0072% w / w, more preferably still between 0.002 and 0.0054% w / w of 0.075 M sulfuric acid, calculated based on the total weight of the composition.