3,6-diazabicyclo 3.1.1 heptanes as neuronal nicotinic acetylcholine receptor ligands

摘要

"3,6-diazabicyclo [3.1.1] heptanes as acetylcholine neuronal nocotinic receptor ligands". The present invention relates to compounds which bind and modulate the activity of neuronal nicotinic acetylcholine receptors (nrrs), processes for the preparation of such compounds, pharmaceutical compositions containing such compounds and methods of using such compounds for the treatment of such compounds. of a wide variety of conditions and disorders, including those associated with central nervous system (CNS) dysfunction. The present invention includes compounds that bind with high affinity to nnrs of the & 4b2 subtypes or the & 6-containing subtype or both nnr subtypes. formula (i) wherein: each m is identical and is 0 or 1: each n is identical and is 0 or 1; when each m is 0, then each n is 1; when each m is 1, then each n is 0; r1 is -c (o) - r3, -c (o) o-r3, -c (o) nh-r3, -c (o) - (ch2) qx-xr3, -c (o) o- (chh2 ) qx-r3, or -c (o) nh- (ch2) qx-r3; q is 1,2,3,41,5, or 6; x is -o-, -s-, -nh-, or -nhc (o) -; R2 is h or alkyl; R3 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, or heterocyclic.