compound, composition, method for preparing a composition, use of a compound, and methods for treating diseases, for inhibiting an allergic dust mite peptidase, for exterminating mites, for controlling a population of mites

摘要

"compound, composition, method for preparing a composition, use of a compound, and methods for treating diseases, for inhibiting a mite peptidase allergen, for exterminating mites, for controlling a population of mites" The present invention relates to generally within the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of formula (x) (referred to herein collectively as "pva compounds"), which, inter alia, inhibit a mite peptidase allergen. dust from group 1 (eg der p 1, der f 1, eur m 1). The present invention also relates to pharmaceutical compositions comprising said compounds, and to the use of said compounds and compositions, both in vitro and in vivo, to inhibit a group 1 mite peptidase allergen, and in the treatment of diseases and disorders. which are mediated by a group 1 dust mite peptidase allergen; which are enhanced by inhibition of a group 1 mite peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition that is triggered by mite; an allergic condition that is triggered by a group 1 mite peptidase allergen; and canine atopy.