Novel cathepsin protease inhibitors are useful in the treatment of, for example, autoimmune disorders, allergies and chronic pain conditions.

摘要

novel cathepsin protease inhibitors are useful in the treatment of, for example, autoimmune disorders, allergies and chronic pain conditions. These are compounds of formula (I) wherein r2a and r2b are independently h, halo C1 -C4 alkyl, C1 -C4 haloalkyl or C1 -C4 alkoxy, or R2a and R2b together with the carbon atom substituted with 1-3 substituents. independently selected from halo, C1 haloalkyl, C1 -C4 alkoxy, C1 -C4 haloalkoxy; or R3 is a C1 -C4 alkyl chain having at least 2 chloro substituents or 3 fluoro substituents; or R 3 is C 3 -C 7 cycloalkylmethyl, optionally substituted by 1-3 substituents independently selected from C 1 -C 4 alkyl, halo, C 1 -C 4 haloC 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy: R 4 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C1 -C6 alkoxy, C1 -C6 haloalkoxy, C1 -C6 alkylamino, C1 -C6 dialkylamino or; R4 is het or carbocyclic, one of which is optionally substituted by 1-3 substituents; n is 12 or 3; for use in the prophylaxis or treatment of a disorder characterized by inappropriate cathepsin expression or activation.