therapeutic or prophylactic agent for a chorioretinal degenerative disease, and prophylactic or therapeutic method for a chorioretinal degenerative disease

摘要

Provided is a novel prophylactic or therapeutic agent for a chorioretinal degenerative disease. The compound of formula (1) or its salt has inhibitory effects on photoreceptor cell death or visual cell death in a mouse model of light damage. Therefore, the compound or its salt is useful as a prophylactic or therapeutic agent for a chorioretinal degenerative disease such as age-related macular degeneration, retinitis pigmentosa. In the formula(1), A is a group (p1), (p2) or (p3); R 1 is H, alkyl, aralkyl or OH or its ester; R 2 is H or alkyl; R 3 is halogen, H, alkyl or OH or its ester; R 4 is halogen, H, OH, alkoxy, amino, alkylamino or cycloalkylamino, R 3 and R 4 may be joined to each other through N to form an unsaturated [1,2,4]oxadiazine ring; R 5 is H, alkyl or cycloalkyl; m is 0 or 1; and n is 0 or 1.