A Modulator of cyclic AMP GMP synthase (cGAs), Pharmaceutical compositions thereof, and methods to design and characterize a Modulator of cGAs

摘要

The invention refers to a new cyclic gmp-amp (cgamp) analogue,CGA modulators and their pharmaceutical ingredients. In addition, the invention refers to a method for designing or characterizing a multi-component gas copolymer modulator or a method for designing and / or characterizing a multi-component gas copolymer modulator or a computer readable environment, including a multi-component gas copolymer crystal structure or its coordination structure, a. Containing (s) and (or) submitted; a polyaromatic gas aromatics inhibitor;and a designed cGAS inhibitor. The invention also relates to a crystalline or crystallizable composition comprising or containing a cGAS polypeptide and a kit comprising one or more cGMPA compounds and optionally one or more cGAS molecules.