Drug composition alliance and this epsilon

摘要

The present invention provides a general formula for heterocyclic compounds (1): where R1 is a group of R5 Z1 Z1 is - equal lower, equal alpha lambda_lambda_group Ask. And R5 is a set of general formula: R13 is hydrogen atom and so on.M is an integer, from 1 to 5, R2 is a hydrogen atom; Y is CH or N, and A1 ring is chosen from_delta_lambda _delta________, at least one of which is replaceable, T is a group - and so on.R3, R4 are hydrogen atoms, R3, R4 are optional____uuuuuuuuuuuuuuuuuuuuuuuuu The Y-junction can be connected to form a 5-10-member to saturated epsilon________ring, which is a ring of epsilon___ There may be at least one ligand.The heterocyclic compounds of the invention have good inhibition of the generation and / or treatment of collagen.