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Conjugates of maytansinoid DM1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours
Conjugates of maytansinoid DM1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours
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机译:美登木素生物碱DM1与抗体曲妥珠单抗的缀合物(通过不可裂解的接头连接)及其在肿瘤治疗中的用途
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摘要
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a noncleavable linker and the cell-binding agent binds to cells of the selected cell population.
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