HUMANIZED ANTIBODIES AGAINST CD134 (OX40) AND APPLICATIONS OF THE SPECIFIED ANTIBODIES

摘要

In accordance with the present invention, antibodies that specifically bind to human CD134 are provided. Antibodies against human CD134 specifically bind to the extracellular domain of human CD134, including domains that do not bind OX40 ligand (OX40L), in human CD134, which are expressed on, for example, activated traditional effector CD4 and / or CD8 T lymphocytes (Teff) of human on activated suppressive regulatory CD4 T-lymphocytes (Treg) person. Humanized antibodies against human CD134 can be used (for example, to mobilize Teff effector function against cancer and / or to inhibit Treg suppressive function) in the treatment of cancer.