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PEPTIDE INDUCING ANTI-TUMOR IMMUNE RESPONSE AND USE THEREOF

机译:肽诱导的抗肿瘤免疫反应及其用途

摘要

The present invention relates to peptides stimulating anti-tumor immune response, wherein said peptides bind to a human major histocompatibility complex (MHC) class I or II, and wherein said peptides are capable of stimulating CD4 and/or CD8 T cells, and to the use thereof in vaccines for the treatment of cancer. The present invention also relates to nucleic acids encoding said peptides, vectors expressing said peptides, host cells comprising said nucleic acids, and to the use thereof in vaccines for the treatment of cancer, as well as to methods for producing said peptides and activated cytotoxic T lymphocytes and to kits for inducing anti-tumor immune response.
机译:本发明涉及刺激抗肿瘤免疫应答的肽,其中所述肽与人主要组织相容性复合体(MHC)I或II类结合,并且其中所述肽能够刺激CD4和/或CD8T细胞,并且涉及在疫苗中的用途,用于治疗癌症。本发明还涉及编码所述肽的核酸,表达所述肽的载体,包含所述核酸的宿主细胞,及其在疫苗中的用途,用于治疗癌症,以及涉及产生所述肽和活化的细胞毒性T的方法。淋巴细胞和试剂盒,以诱导抗肿瘤免疫反应。

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