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METHOD FOR STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLES

机译:双环杂环立体合成的方法

摘要

Disclosed herein is a method for stereoselectively producing compounds of the formulae (1A) and (1B)particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, also disclosed is the use thereof for the treatment of different diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.
机译:本文公开了一种立体选择性地制备式(1A)和(1B)的化合物,特别是其与无机或有机酸和碱的生理上可接受的盐的方法,其具有有价值的药理特性,特别是对酪氨酸激酶介导的信号转导的抑制作用还公开了其在治疗不同疾病中的用途,特别是肿瘤疾病以及良性前列腺增生(BPH),肺和气道疾病。

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