Recombinant measles virus useful as a bivalent vaccine against measles and malarial infection

摘要

The object of the present invention is to provide a vaccine which is safe and effective against malarial infection and a vector which is used in the manufacture of this vaccine and to provide a bivalent vaccine which exhibits an excellent preventive effect against measles virus and malarial infection and which eliminates complexity at the time of inoculation. The present invention provides a recombinant measles virus in which is inserted a gene which encodes a protein involved in preventing malarial infection in the measles virus genome. The protein involved in preventing malarial infection is preferably selected from pfEMP-1, MAEBL, AMA-1, MSP-1, LSA-1, Pfs230, and the like. The present invention also relates to a bivalent vaccine against measles and malarial infection which contains the recombinant measles virus, and an antiserum obtained from body fluid taken from an animal infected with the recombmant measles virus. It also provides a method of manufacturing a vaccine against malarial infection which is characterized by using a measles virus as a vaccine vector in the manufacture of a vaccine against malarial infection.