RECOMBINANT MEASLES VIRUS USEFUL AS A BIVALENT VACCINE AGAINST MEASLES AND NIPAH INFECTIONS

摘要

The object of the present invention is to provide a vaccine which is safe and effective against Nipah virus infection and a vector which is used in the manufacture of this vaccine and to provide a bivalent vaccine which exhibits an excellent preventive effect against measles virus and Nipah vuns infection and which eliminates complexity at the time of inoculation. The present invention provides a recombinant measles virus in which is inserted a gene which encodes a protein involved in preventing Nipah infection into the measles virus genome. The protein involved in preventing Nipah virus infection is preferably G protein or F protein which is a membrane protein. The present invention also relates to a bivalent vaccine against measles and Nipah virus infection which contains the recombinant measles virus, and an antiserum obtained from body fluid taken from an animal infected with the recombinant measles virus. It also provides a method of manufacturing a vaccine against Nipah virus infection which is characterized by using a measles virus as a vaccine vector in the manufacture of a vaccine against Nipah virus infection.