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Novel compounds of 1 ibeta hydroxy steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
Novel compounds of 1 ibeta hydroxy steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
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机译:1 ibeta羟基类固醇的新型化合物,用于线粒体生物发生和与线粒体功能障碍或耗竭有关的疾病
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摘要
The present invention provides novel compounds of 11ß hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria for treating or preventing diseases relating to mitochondrial dysfunction or depletion and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat prevent or reverse injury to or depletion of mitochondria.
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