3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer

摘要

24567The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal wherein i.a. R is an optionally substituted heterocycle or optionally substituted aryl; and one of R R Rand R is a substituted heterocycle or substituted aryl.