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RAPIDLY DISINTEGRATING TASTE-MASKED TABLET

机译:快速分解口味的平板电脑

摘要

The present invention concerns a rapidly disintegrating taste-masked tablet comprising: at least one active principle selected from the group comprising mineral salts, vitamins, and mixtures thereof, at least one sweetening agent, preferably a low calorie and anticariogenic sugar substitute selected from the group comprising saccharin, cyclamate, aspartame, acesulfame K and alitame, preferably aspartame, optionally at least one flavouring agent, preferably a synthetic flavouring agent, starch and microcrystalline cellulose, which are binding agents with disintegrating properties, at least one free flow aid, and preferably colloidal silicon dioxide, and optionally at least one lubricating agent, selected in the group comprising magnesium stearate, micronized stearic acid and talc, and preferably magnesium stearate, characterized in that: the active principle is coated by the sweetening agent, and optionally, the flavouring agent, the weight ratio of the sweetening agent to the active principle ranges from 0.2 to 3, preferably from 0.2 to 2.1, and more preferably from 0.6 to 1.8, the weight ratio of starch to microcrystalline cellulose ranges from about 0.76 to 0.85, and preferably about 0.8. It also concerns a method for the preparation of such a tablet.
机译:本发明涉及一种快速崩解的掩味片剂,其包含:至少一种选自矿物质盐,维生素及其混合物的活性成分,至少一种甜味剂,优选选自低卡路里和抗龋糖的替代物包含糖精,甜蜜素,阿斯巴甜,乙酰磺胺酸钾和阿米甜,优选阿斯巴甜,任选地至少一种调味剂,优选合成调味剂,淀粉和微晶纤维素,它们是具有崩解性质的粘合剂,至少一种自由流动助剂,并且优选选自硬脂酸镁,微粉化的硬脂酸和滑石的胶态二氧化硅和任选的至少一种润滑剂,优选硬脂酸镁,其特征在于:活性成分被甜味剂和任选的调味剂包衣剂,甜味剂与活性成分的重量比淀粉的重量比为0.2至3,优选为0.2至2.1,更优选为0.6至1.8,淀粉与微晶纤维素的重量比为约0.76至0.85,并且优选为约0.8。它还涉及用于制备这种片剂的方法。

著录项

  • 公开/公告号IN275079B

    专利类型

  • 公开/公告日2016-08-26

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN423/KOLNP/2006

  • 发明设计人 EQUIPART PAUL;

    申请日2006-02-24

  • 分类号A61K33/06;

  • 国家 IN

  • 入库时间 2022-08-21 14:24:27

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