The polymorphic crystalline form V of 1- 4- (5-cyano-indole-3- yl) butyl -4- (2-carbamoyl-benzofuran-5-yl) -piperazine hydrochloride monohydrate, methods for its preparation, use and pharmaceutical compositions containing them

摘要

The polymorphic crystalline form V of 1- [4- (5-cyano-indol- 3-yl) - butyl] -4- (2-carbamoyl-benzofuran-5-yl) -piperazine hydrochloride monohydrate having the following X-ray diffraction data shown in the sequence ID. interplanar distance d nm, the angle 2 and the intensity ratio I / I0: 1, 0.9466, 9.34, 14; 2, 0.8166, 10.83, 15; 3, 0.6807, 13.00, 20; 4, 0.6569, 13.47, 12; 5, 0.4742, 18.70, 16; 6, .4563, 19.44, 100; 7, 0.4416, 20.09, 32; 8, 0.4231, 20.98, 12; 9, .3503, 25.41, 64; and 10, 0.3408, 26,13, 14, and a pharmaceutical composition containing it. The form of such a composition for the treatment or prevention of depressive disorders, anxiety, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarction, for the therapy of side- effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation. Methods for making the form and its use for the manufacture of a medicament.