the sterolo derivatives, method for preparing the same, pharmaceutical compositions containing the same and their use for the treatment of glioblastoma multiforme.

摘要

Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n; R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2); n : 1-3; R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3; R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6; R, R4 : H, 1-12C alkyl or optionally substituted aryl; R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR); R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR); B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR); R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8; and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I); and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.