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STEROL DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF FOR THE TREATMENT OF MULTIPLE GLIOBLASTOMAS
STEROL DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF FOR THE TREATMENT OF MULTIPLE GLIOBLASTOMAS
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机译:固醇衍生物,其制备方法,包含相同成分的药物组合物及其用于治疗多发性胶质瘤的方法
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摘要
Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n; R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2); n : 1-3; R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3; R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6; R, R4 : H, 1-12C alkyl or optionally substituted aryl; R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR); R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR); B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR); R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8; and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I); and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.
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