NOVEL METHOD TO PRODUCE MAGNESIUM-DOPED BIPHASIC CALCIUM PHOSPHATE

摘要

1 3 METHOD TO PRODUCE MAGNESIUM-DOPED BIPHASIC CALCIUM PHOSPHATE ABSTRACT THIS INVENTION RELATES TO A METHOD IN PRODUCING MAGNESIUM-DOPED 5 BIPHASIC CALCIUM PHOSPHATE. CALCIUM PHOSPHATE IS AN INTERESTING MATERIAL FOR BONE IMPLANT APPLICATIONS, AS IT SHOWS BIOCOMPATIBILITY AND BIOACTIVITY TO TISSUE BONE. AMONG CALCIUM PHOSPHATE-BASED MATERIALS, BIPHASIC CALCIUM PHOSPHATE (BCP), A MIXTURE OF NON- RESORBABLE HYDROXYAPATITE (14A) AND RESORBABLE TRICALCIUM PHOSPHATE (TCP), HAS SHOWN TO POSSESS UNIQUE CHARACTERISTICS APPROPRIATE FOR BONE REPLACEMENT. DOPING OF MAGNESIUM IONS INTO BCP WILL BRING BIOLOGICAL IMPROVEMENT. MAGNESIUM ION WAS FOUND TO CAUSE THE 10 ACCELERATION OF NUCLEATION KINETICS OF BONE MINERALS. MAGNESIUM DEPLETION ADVERSELY AFFECTS ALL STAGES OF SKELETAL METABOLISM, LEADING TO DECREASE IN OSTEOBLASTIC ACTIVITIES AND BONE FRAGILITY. THEREFORE, THE INCORPORATION OF MAGNESIUM IONS INTO THE CALCIUM PHOSPHATE STRUCTURE IS OF GREAT INTEREST FOR THE DEVELOPMENT OF ARTIFICIAL BONE CAT NG A AMMONM 15 SOLINIAN N STIRRING UNTIL A DISSOLVED CLEAR SOLUTION 20 OURING IN FORM OF AQUEOUS SOUTION OF URN NITRATE LETRA-HYDRATE AND MAGNESIUM -71 EP. NITRATE HNA@HYDRATE F@@NG CH AMMONIUM HYDROGEN PHOSPHATE AND UREA 25 UX N 30