Hypoallergenic chimeric proteins belonging to the family of lipid transfer of Parietaria judaica for use in the treatment of allergies

摘要

A chimeric protein comprising amino acid sequences derived from the sequences corresponding to the main allergens of the Jewish Parietaria pollen known as Par j 1 and Par j 2, the amino acid sequence of the chimeric protein lacks one or more epitopes for binding to IgE antibodies corresponding to the sequences from which it is derived, and wherein the protein does not have a reduction in immunogenicity, characterized in that the protein comprises the amino acid sequence of sec. with no. ID: 4.