T lymphocyte activation inhibitor, pharmaceutical composition containing it and screening method for T lymphocyte activation inhibitor substances

摘要

An inhibitor of a molecule of repulsive orientation to (RGMa) as an active ingredient for use in the prophylaxis or treatment of an autoimmune disease, such as cellular autoimmune disease, rheumatism, multiple sclerosis, autoimmune diseases of the nervous system, such as syndrome of Guillin-Barré, neuro-Behçet disease, malignant anemia, type I diabetes, systemic lupus erythematosus (SLE), inflammatory bowel diseases (IBD), Sjogren's syndrome, atopic dermatitis, Goodpasture's syndrome, Grave's diseases, hemolytic anemia autoimmune, autoimmune thrombocytopenic purpura, glomerulonephritis, myasthenia gravis, Hashimoto's diseases.