Improved method of producing intermediates for the production of macrocycles that are inhibitors of the proteasomal degradation of p27, such as argirine and its derivatives

摘要

An optionally protected L-4-methoxytryptophan production process comprising the synthesis of the protected L-4-methoxy tryptophan methyl ester according to formula 2, starting from a compound according to formula 1 ** Formula ** comprising asymmetric hydrogenation using [1S, 1S ', 2R, 2R'-DuanPhos Rh (cod)] BF4 as catalyst.