Deuterated isoindolin-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors

摘要

A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from CH3, CH2D, CHD2 and CD3; R2 is CH3 or CD3; R3 is CD3; R4 is an ethyl group substituted with zero to five deuterium atoms, or is a cyclopentyl group substituted with zero to nine deuterium atoms; X is selected from CH2, CHD, CD2 and C = O; each of Y1a, Y1b, Y2, Y3, Y4, Y5, Y7 and Y8 is independently selected from H and D; Y6 is selected from Cl, H and D; and in which the isotopic enrichment factor for each designated deuterium atom is at least 6,000.