Glucocorticoid receptor agonist comprising derivatives of 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline having a substituted oxy group

摘要

A compound represented by formula (1) or a salt thereof, for use in the prevention or treatment of a disease: wherein R1 represents formulas (2a), (3a), (4a) or (5a); R2 represents - (CO) -R8, - (CO) O-R9, - (SO) -R10, - (SO2) -R11 or - (CO) NR12R13; R2-O- is substituent at position 4 or 5 of benzene ring A; R3 represents an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms; R4, R5, R6 or R7 represents a halogen atom, an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have one substituent, an alkenyl group having 2 to 8 carbon atoms, preferably 2 to 6 carbon atoms, an alkynyl group having 2 to 8 carbon atoms, preferably 2 to 6 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, preferably of 1 to 6 carbon atoms, a nitro group or a formyl group m, n, p or q represents 0.1 or 2; in the case where m, n, p or q is 2, each R4, R5, R6 or R7 can be the same or different; R8, R9, R10 or R11 represents an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have one substituent, an alkenyl group having 2 to 8 carbon atoms, preferably from 2 to 6 carbon atoms, a cycloalkyl group having from 3 to 10 carbon atoms, preferably from 3 to 8 carbon atoms, an aryl group which may have one substituent or a heterocyclic group which may have one substituent; R12 and R13 may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, preferably 1 to 6 carbon atoms, which may have a substituent, an aryl group which may have a substituent or a heterocyclic group, wherein the disease is selected from the group consisting of an inflammatory eye disease and a dermatitis selected from the group consisting of acute eczema, subacute eczema, chronic eczema, contact dermatitis, nummular eczema, self-sensitization dermatitis, childhood eczema, chronic Vidal lichen simplex, seborrheic dermatitis, progressive palmar tyloid keratoderma, genital / anal eczema, eczema / dermatitis of the external ear canal or pinna, eczema / dermatitis around the nasal vestibule and fin of the nose, prurigo, urticaria, psoriasis, acrodermatitis, impetigo nerpetiformis, Reiter's syndrome, palmoplantar pustulosis, lichen planus, erythema, anaphyla purpura ctoid, Weber-Christian disease, oculocutaneous syndrome, Reynaud's disease, alopecia areata, pemphigus, Dühring's dermatitis herpetiformis, herpes zoster, erythroderma, lupus miliaris disseminates faciei, allergic angitis, pityriasis lichenoides et varioles, chronic and neonatal sclerema.